Realistic expectations of prepulse inhibition in translational models for schizophrenia research
نویسندگان
چکیده
منابع مشابه
Prepulse facilitation and prepulse inhibition in schizophrenia patients and their unaffected siblings.
BACKGROUND Deficits in schizophrenia patients and their first-degree relatives have been reported in prepulse inhibition (PPI), a phenomenon that measures an early stage of information processing (sensorimotor gating). It is less clear whether these information processing deficits extend to prepulse facilitation (PPF), which measures a later stage of generalized alerting or orienting. METHODS...
متن کاملEffective neuroleptic medication removes prepulse inhibition deficits in schizophrenia patients.
BACKGROUND The magnitude of the startle eyeblink response is reduced if the startle eliciting stimulus is shortly preceded by another stimulus. There is evidence that schizophrenia patients exhibit impairments in this so-called prepulse inhibition. Our study investigated whether prepulse inhibition is affected by neuroleptic drug treatment as is suggested by animal research. METHODS Prepulse ...
متن کاملReduced Prepulse Inhibition as a Biomarker of Schizophrenia
The startle response is composed by a set of reflex behaviors intended to prepare the organism to face a potentially relevant stimulus. This response can be modulated by several factors as, for example, repeated presentations of the stimulus (startle habituation), or by previous presentation of a weak stimulus (Prepulse Inhibition [PPI]). Both phenomena appear disrupted in schizophrenia that is...
متن کاملPrepulse-elicited startle in prepulse inhibition.
BACKGROUND Prepulse inhibition (PPI) has become a major experimental paradigm in the study of psychiatric disorders. In this study, a potential confound in measurement and interpretation of PPI, namely startle reactions to so-called "nonstartling" prepulses, was examined. METHODS Prepulses of 80, 85, and 90 dB(A) were presented on their own or followed by a pulse of 115 dB(A) (lead interval: ...
متن کاملLinking Stress and Schizophrenia: A Focus on Prepulse Inhibition
Schizophrenia affects about 0.5-1.0% of people worldwide, occurring roughly equally in both men and women. The exact causes of schizophrenia are not fully understood, although the consensus of current research is that schizophrenia is a developmental disorder, caused by a genetic liability interacting with environmental and psychosocial stress. However, the possible neurobiological mechanisms u...
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ژورنال
عنوان ژورنال: Psychopharmacology
سال: 2008
ISSN: 0033-3158,1432-2072
DOI: 10.1007/s00213-008-1072-4